J Sebag, USA

The Inaugural Robert Machemer Lecture: Vitrectomy for Vision Degrading Myodesopsia

 J. Sebag, MD, FACS, FRCOphth, FARVO

Vitreous is the largest but perhaps least understood part of the eye. Routine surgical removal of vitreous and apparent tolerance of the eye have resulted in the notion that vitreous has little importance. However, recent scientific discoveries have defined important roles for vitreous in ocular health and disease, enabling new strategies of therapy and prevention. For example, antioxidant properties in vitreous are now known to be important in maintaining lens clarity and probably in mitigating against other manifestations of oxidative stress, which may influence future approaches to vitrectomy surgery.

Dr. Sebag’s keynote lecture at SOE 2019 will review the molecular organization of vitreous and the significant structural changes that occur throughout life. Recent observations and investigations have identified how alterations in the vitreous body with myopia, aging, and disease result in vision loss. Indeed, it has recently been discovered that an event as seemingly simple as posterior vitreous detachment (PVD) can have profound impacts on vision, specifically degradation in contrast sensitivity function. Anomalous PVD will be presented as a unifying concept in better understanding vitreo-retinopathies, especially those that afflict the macula. New therapeutic paradigms will be discussed, with particular emphasis on  limited vitrectomy for Vision Degrading Myodesopsia, disease result in vision loss, and how vitrectomy can restore normal vision


Brief Biography J. Seabag

Upon graduating from the Bronx High School of Science in 1969 & Columbia College in 1973, Jerry Sebag conducted research at the Karolinska in Stockholm. In 1979, he was conferred an MD degree by the Columbia College of Physicians & Surgeons, where he began vitreous research. Following a residency in Ophthalmology at Harvard Medical School, Dr. Sebag was awarded a Guggenheim Fellowship to conduct research at INSERM in Paris. Upon completion of a vitreo-retinal fellowship at Harvard in 1986, Dr. Sebag established the VMR Institute for Vitreous Macula Retina in California.

Considered a leading authority on vitreous, Dr. Sebag has authored 3 books, 74 original articles, 67 chapters, and 64 editorials, reviews, & letters (Google Scholar H-Index=43). A fellow of the American College of Surgeons and the Royal College of Ophthalmologists (UK), Dr. Sebag has delivered named lectures throughout the world and received many awards, including First Prize from the American Health Foundation, a prize at the Harvard Medical School Bicentennial Program, the Treacher-Collins Prize of the Ophthalmological Society of the UK, the Heed and Knapp Fellowships, and honor awards from the American Academy of Ophthalmology, the Vitreous Society, and the Fondazione Bietti in Rome. In 2006 Dr. Sebag was inducted as a member of the venerable and prestigious American Ophthalmological Society. In 2010 he was selected as a Fellow of ARVO.