Fotis Topouzis, Greece

Glaucoma is listed among the leading causes of visual impairment and blindness, while the number of people affected by the disease is expected to increase worldwide. Therefore, determining the disease prevalence, incidence and risk factors remains mandatory.

The Thessaloniki Eye Study (TES) is one of the few longitudinal studies of chronic eye diseases focused on Southern European populations. The population-based study design and the robust methodology led to accurate estimates regarding the burden of open-angle glaucoma (OAG), the risk factors and genetic background associated with OAG, and the probability of developing OAG within a 12-year period. The identified high rates of undiagnosed OAG and OAG overdiagnosis have highlighted the need for refinement in clinical practice.

Pseudoexfoliation syndrome (PEX) was one of the risk factors that have been associated with increased OAG prevalence in TES. Because of the high prevalence of PEX and pseudoexfoliaton glaucoma (PEXG), the study provided a suitable dataset for further investigation of this syndrome that has been consistently associated with increased risk of glaucoma prevalence, incidence, and progression. Novel relationships between ocular or systemic factors and PEX and/or PEXG incidence were identified in TES and have recently been added to the limited literature data.

TES was the means to a 20-year journey towards gaining further insight into glaucoma, by both verifying previous associations and introducing new ideas shedding light on the disease burden and pathophysiology.

Brief Biog

Professor Fotis Topouzis received his MD from the Aristotle University of Thessaloniki, Greece in 1986. Topouzis pursued residency training in Ophthalmology at the “Saint-Antoine” Hospital and National Center of Ophthalmology “Quinze Vingts” Hospital Paris, France in 1990. In 1992 he received his Ph.D. in Psychophysics at the Democritus University of Thrace, Alexandroupolis, Greece. He completed his Fellowship in comprehensive ophthalmology and cornea at the National Center of Ophthalmology “Quinze Vingts” Hospital Paris, France as “Assistant Specialiste des Hopitaux de Paris” in 1993. He completed his Fellowship in glaucoma at the Jules Stein Eye Institute, Los Angeles, CA, USA in 1998. In 2001 he became Lecturer in Ophthalmology at the Aristotle University of Thessaloniki and the Head and Founder of the Laboratory of Research and Clinical Applications in Ophthalmology. Professor Topouzis is currently Chair of the 1st Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital. Professor Topouzis has participated one visiting professorship: Jules Stein Eye Institute, Los Angeles, CA.


Professor Topouzis has received the distinguished foreign resident Award from the College of Medicine of the Hospitals in Paris, Post –Doctoral Award from the Aristotle University of Thessaloniki, Greece and Shaffer International Fellowship Award from the Glaucoma Research Foundation, San Francisco, CA.


Professor Topouzis serves 5 ophthalmology journal editorial boards and as a reviewer for 27 ophthalmology journals. He is currently the Vice President of the European Glaucoma Society (EGS), the Chair of the Program Planning Committee of EGS and the Co-Chair of the Program Committee of the Glaucoma Research Society.  He is also a member of the Board of Governors of the World Glaucoma Association, Professor Topouzis is especially interested in epidemiology and clinical and genetic research in ophthalmic diseases with particular focus in glaucoma, age-related macular degeneration and diabetic retinopathy. He is Principal Investigator of two large population-based studies (Thessaloniki Eye Study, Eureye Study).